Stefan reveals that this woman caused the brothers to feud 145 years ago, and turned them into vampires.He says that she was adopted and is actually a descendant of Katherine, and that he saved her the night of her parents' deaths.She claims that choosing Stefan was the best choice she'd ever made.However, their relationship ends due to her heightened feelings for Damon.The sacrifice later takes place, but Elena is saved because John sacrificed himself for her after Bonnie magically enchants him.However, her Aunt Jenna is turned into a vampire and, as part of the sacrifice, is killed by Klaus, leaving Elena without a guardian.Stefan's brother, Damon, also begins falling for Elena.
She later admits to Stefan that she has feelings for Damon as well, but that she never stopped loving Stefan.
She is kidnapped and experimented on by Wes Maxfield, and learns that her father experimented on vampires.
Later, when Katherine is about to die as a result of the past 500 years catching up with her, Katherine uses a spell to possess Elena.
She loses trust in Damon, partly because he killed her friend Aaron, so they break up, but soon get back together.
Once Markos and his Traveler army begin to take over Mystic Falls, Elena and company come up with a plan to neutralize the Travelers by killing them all at the same time, overpowering Bonnie – who is now the anchor to the Other Side – and creating a possible way out of the collapsing dimension.